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Thiago Silva limped off the pitch with an apparent leg injury in the first half of Chelsea's clash with Tottenham.
Silva was unable to continue after receiving treatment from Chelsea's medical staff on the pitch, with Andreas Christensen subsequently brought on as his replacement.
The 36-year-old was making his 17th Premier League appearances for the Blues since joining the club on a free transfer, and his third under new head coach Thomas Tuchel.
Silva has previously worked with Tuchel at Paris Saint-Germain, who allowed him to leave at the end of his contract in August before sacking the German tactician four months later.
The veteran defender was sad to see Frank Lampard lose his job at Stamford Bridge, but has admitted that he is glad to have been reunited with a manager he knows very well.
"I am left with mixed feelings. Sadness for one, happiness for the other. But life has to go on and we have to turn our results around," he said last week.
"The six months I spent working with Frank were fantastic, and I have two unbelievable years with Thomas Tuchel in Paris too, including getting to the final of the Champions League. That was a really great year for everyone at PSG. So it’s a special moment for me with his arrival here."
Chelsea are seeking a third successive clean sheet against Spurs, having drawn 0-0 with Wolves and beaten Burnley 2-0 in their first two games with Tuchel at the helm.
Silva had featured in the centre of a three-man defence in those fixtures, and started in the same position for the London derby, but was unable to see out the full 90 minutes this time around.
The Blues will hope that that the issue doesn't keep him out of action for any length of time, with a trip to Sheffield United looming large on the horizon.