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Angel Di Maria will miss Paris Saint-Germain's Champions League round of 16 first-leg tie with Barcelona later this month through injury.
Mauricio Pochettino has now confirmed that the injury is serious enough to keep the 32-year-old wingerout of the club's crucial European showdown against Barca on February 16.
When asked if Di Maria will be unavailable for the trip to Camp Nou, the PSG head coach told a press conference on Tuesday:"Yes, It's over for Angel Di Maria To play against FC Barcelona.
"We will communicate in a week to see where we are."
PSG will be without the Argentinewhen they take in a trip to Caen in the Coupe de France on Wednesday, and he will also beforced to sit out a Ligue 1 meeting with Nice on Saturday, which the French champions must win to stay within touch of current leaders Lyon.
Pochettino's side are due to face Monaco five days after with encounter with Barca, but it remains to be seen whether or not Di Maria will be fit to return for that fixture given the fact no specific timeframe for his recovery has been given as of yet.
Di Maria has been a talismanic figure for PSG once again this season, contributing five goals and 12 assists to their cause across 25 appearances in all competitions.
However, the mercurial winger's current contract is due to expire at the end of June, and a serious injury could damage his chances of earning an extension.
Di Maria addressed speculation over his future at Parc des Princes back in September, telling Canal Plus: "I want to end my European career here, but it's not only up to me."