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Manchester United welcome Southampton to Old Trafford on Tuesday evening as Ole Gunnar Solskjaer's men aim to get back to winning ways in the Premier League.
The Saints head to the north-west of the country following three successive Premier League defeats, the most recent of which came on Saturday against Aston Villa.
The visitors have a number of players missing with Theo Walcott, Oriol Romeu, Ibrahima Diallo, Mohamed Salisu, Nathan Tella, Kyle Walker-Peters, Michael Obafemi, Will Smallbone and Jannik Vestergaard all out.
United still cannot call upon the services of Phil Jones, while Scott McTominay had to go off against Arsenal with stomach cramps and is being assessed.
The 2-1 defeat by Sheffield United was the Reds' fourth home league loss of the season and Old Trafford has been far from a fortress this term.
Despite their recent struggles in the top-flight, Southampton's away form will lead them to believe they can get something out of the game, with the Saints losing just two of their last 14 league fixturesaway from St Mary's Stadium.
The most recentmeeting between these two sides came on November 29 when Solskjaer's team came from 2-0 down to win 3-2, while the last clashat Old Trafford in July ended in a 2-2 draw.
Southampton have scored in six of their last eight away league games, while United have scored in 13 of their last 16 league clashes in their own stadium, and backing another high-scoring encounter in midweek makes plenty of sense.
Both teams to score has paid out in each of the last five meetings between these two sides and a repeat is priced at 3/4 (1.75).
Odds correct at the time of writing. Please gamble responsibly.