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The result was Germany's worst defeat in almost 90 years – and their worst competitive defeat ever.
Speaking to ARD after the match, Low expressed his disappointment at what he called a "pitch-black day" for the 2014 World Cup champions.
"It's hard to explain at the moment, we had a pitch-black day when nothing worked at all," Low said. "Everything was really bad today in every respect. You couldn't find anything good. We wanted to be brave and play forward but nothing worked today –neither offensively or defensively.
"After the first goal we gave up our whole concept. We opened up and the Spaniards were so goodthat they took advantage of it. No organisation, no proximity to the players, no communication. We gave up order and that was deadly."
After a performance like the one his side turned in, Low was inevitably going to be asked about axed trio Thomas Muller, Jerome Boateng and Mats Hummels.
In a stunning move in March 2019,Low announced that all three players, then at Bayern Munich, wouldno longer be considered for international selection.
The trio have continued to perform well for their club sides in the meantime, with Hummels having moved back to Borussia Dortmund last summer.
Low, however, continued to maintain that he would not consider reversing his decision on the three players, despite Tuesday's heavy defeat.
"We have said that we trust the players we have," Low said when asked about the trio. "We were on a good path, but today we have seen that we are not as far along as we thought we would be."